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WELCOME TO THE LANDRETH LAB!
The Landreth lab has two distinct areas of interest that are centered on understanding disorders of the nervous system.
Alzheimer's disease if the primary focus of work in the laboratory. Current projects in the laboratory are directed at understanding how the AÂ peptides are normally cleared from the brain and the roles of inflammation in AD pathogenesis. We are also engaged in identification and validation of new therapeutic agents for the treatment of AD.
The laboratory has a long standing interest in the roles of the ERK MAP kinases in the nervous system.  We have developed murine lines in which ERK1 and ERK2 have been knocked out. Analysis of these mice have revealed unexpected roles for these enzymes in neural crest development, patterning of the developing brain and corticogenesis. The ERK knockouts phenocopy neuro-cardiofacial cutaneous, DiGeorge and related syndromes, and a subset of autism spectrum disorders that arise from genetic perturbations of the ERKs or their upstream regulators. We are attempting to understand the mechanistic basis of these human disorders.
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